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AMD-070 hydrochloride
CAS No. 880549-30-4
AMD-070 hydrochloride ( AMD-11070 hydrochloride )
产品货号. M16387 CAS No. 880549-30-4
CXCR4 的有效选择性拮抗剂，在 CXCR4 125I-SDF 抑制结合测定中 IC50 为 13 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥510 | 有现货 |
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| 5MG | ￥770 | 有现货 |
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| 10MG | ￥1158 | 有现货 |
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| 25MG | ￥2325 | 有现货 |
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| 50MG | ￥3491 | 有现货 |
|
| 100MG | ￥5168 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AMD-070 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CXCR4 的有效选择性拮抗剂，在 CXCR4 125I-SDF 抑制结合测定中 IC50 为 13 nM。
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产品描述A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay; displays no significant activity (IC50>10 uM) for a series of other closely GPCRs (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2); inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 of 2 nM and 26 nM, respectively, with noncytotoxic to cells (>23 uM); exhibits good PK profiles and excellent oral bioavailability; also inhibits CXCR4/SDF-1-mediated events in ALL cancer cells and transplant models.HIV Infection Phase 3 Clinical.
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体外实验——
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体内实验——
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同义词AMD-11070 hydrochloride
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通路GPCR/G Protein
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靶点Chemokine Receptor
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受体Chemokine Receptor
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研究领域Infection
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适应症HIV Infection
化学信息
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CAS Number880549-30-4
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分子量458.8554
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分子式C21H30Cl3N5
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESC1CC(C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3.Cl
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化学全称1,4-Butanediamine, N1-(1H-benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-, hydrochloride (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Skerlj RT, et al. J Med Chem. 2010 Apr 22;53(8):3376-88.
2. Stone ND, et al. Antimicrob Agents Chemother. 2007 Jul;51(7):2351-8.
3. Parameswaran R, et al. Leukemia. 2011 Aug;25(8):1314-23.
